RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

How RNA modifications regulate the antiviral response

MG Thompson, MT Sacco, SM Horner - Immunological reviews, 2021 - Wiley Online Library
Induction of the antiviral innate immune response is highly regulated at the RNA level,
particularly by RNA modifications. Recent discoveries have revealed how RNA …

Spike Protein NTD mutation G142D in SARS-CoV-2 Delta VOC lineages is associated with frequent back mutations, increased viral loads, and immune evasion

L Shen, TJ Triche, JD Bard, JA Biegel, AR Judkins… - MedRxiv, 2021 - medrxiv.org
The significantly greater infectivity of the SARS-CoV-2 Delta variants of concern (VOC) is
hypothesized to be driven by key mutations that result in increased transmissibility, viral load …

The mutational landscape of SARS-CoV-2

B Saldivar-Espinoza, P Garcia-Segura… - International Journal of …, 2023 - mdpi.com
Mutation research is crucial for detecting and treating SARS-CoV-2 and developing
vaccines. Using over 5,300,000 sequences from SARS-CoV-2 genomes and custom Python …

Host-mediated RNA editing in viruses

T Zhu, G Niu, Y Zhang, M Chen, CY Li, L Hao, Z Zhang - Biology Direct, 2023 - Springer
Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common
cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around …

Prediction of recurrent mutations in SARS-CoV-2 using artificial neural networks

B Saldivar-Espinoza, G Macip… - International Journal of …, 2022 - mdpi.com
Predicting SARS-CoV-2 mutations is difficult, but predicting recurrent mutations driven by the
host, such as those caused by host deaminases, is feasible. We used machine learning to …

Inosine and its methyl derivatives: Occurrence, biogenesis, and function in RNA

N Dutta, I Deb, J Sarzynska, A Lahiri - Progress in Biophysics and Molecular …, 2022 - Elsevier
Inosine is one of the most common post-transcriptional modifications. Since its discovery, it
has been noted for its ability to contribute to non-Watson-Crick interactions within RNA …

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

DR Ribeiro, A Nunes, D Ribeiro, AR Soares - Frontiers in Genetics, 2023 - frontiersin.org
Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during
viral infections. By modulating the modification landscape of viral and host RNAs, viruses …

Potential mechanisms for human genome integration of genetic code from SARS-CoV-2 mRNA vaccination

AM Kyriakopoulos, PA Mccullough, G Nigh… - Authorea …, 2022 - advance.sagepub.com
Background The findings of a sequence embedded in Human DNA that was almost identical
to a sequence in the SARS-CoV-2 genome, and the identification of plausible integration of …

The regulation of antiviral innate immunity through non-m6A RNA modifications

S Shen, LS Zhang - Frontiers in Immunology, 2023 - frontiersin.org
The post-transcriptional RNA modifications impact the dynamic regulation of gene
expression in diverse biological and physiological processes. Host RNA modifications play …