The blood–brain barrier (BBB) is a physical structure whose main function is to strictly
regulate access to circulating compounds into the central nervous system (CNS). Vegetable …

Epidemiologic studies have shown that in the aging society, a person dies from stroke every
3 minutes and 42 seconds, and vast numbers of people experience depression around the …

Currently prescribed medications for the treatment of Alzheimer's disease (AD) that are
based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide …

Oxidative and inflammatory signaling pathways have been identified as important targets for
mitigating hypoxic stress-induced neurological complications. Thus, the effects of …

Numerous animal and human studies have assessed the relationship between polyphenols
and outcomes related to depression. However, no comprehensive synthesis of the main …

Social defeat stress (SDS) due to changes in biochemical functions has been implicated in
the pathogenesis of affective and cognitive disorders. Employing pharmacological approach …

Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to
prevent and suppress several human diseases, and are important sources of therapeutic …

While neurotransmitter dysfunction represents a key component in mental illnesses, there is
now a wide agreement for a central pathophysiological hub that includes hormones …

Stress is an important factor in the development of several human pathologies. The
response of rodents and humans to stress depends on many factors; some people and …

Psychosocial stress has been widely reported to contribute to psychiatric disturbances.
Perturbations in the enzymes of GABAergic and cholinergic systems have been implicated …