The isoxazolidine ring represents one of the privileged structures in medicinal chemistry,
and there have been an increasing number of studies on isoxazolidine and isoxazolidine …

The preparation of chiral compounds is an important and challenging area of contemporary
synthetic organic chemistry. 1 The 1, 3-dipolar cycloaddition, also known as the Huisgen …

Covering: July 2001 to December 2012 This review covers pyrrolizidine alkaloids isolated
from natural sources. Topics include: aspects of structure, isolation, and biological …

The synthesis of polyhydroxylated indolizidines and pyrrolizidines belonging to the class of
iminosugars, endowed with a vast and assorted biological activity, can be achieved in a …

Herein we report a mild, transition-metal-free, highly diastereoselective Lewis acid catalyzed
methodology toward the synthesis of isoxazolidine-based diazo compounds from the …

Three decades after their first synthesis, iminosugar C-glycosides have become an
important class of iminosugars with promising biological and therapeutic properties. The …

A concise total synthesis of (+)-hyacinthacine A2, a polyhydroxylated pyrrolizidine alkaloid,
is described using our recently discovered inversion of the C− N bond polarity in nitrones. In …

Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources.
The interest of the scientific community in these compounds owes itself to their high toxicity …

A practical method for the synthesis of five-membered iminocyclitols, pyrrolidine alkaloids
bearing multiple hydroxyl substituents, has been developed. All of the eight key …

Glycosidases are extremely widespread enzymes responsible for the cleavage of glycosidic
bonds in glycoconjugates found in living organisms. Although it was well-known that the …