Therapeutic strategies targeting FOXO transcription factors

G Calissi, EWF Lam, W Link - Nature reviews Drug discovery, 2021 - nature.com
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential

TG Martin, MA Juarros, LA Leinwand - Nature Reviews Cardiology, 2023 - nature.com
Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Antihypertrophic memory after regression of exercise-induced physiological myocardial hypertrophy is mediated by the long noncoding RNA Mhrt779

H Lin, Y Zhu, C Zheng, D Hu, S Ma, L Chen, Q Wang… - Circulation, 2021 - Am Heart Assoc
Background: Exercise can induce physiological myocardial hypertrophy (PMH), and former
athletes can live 5 to 6 years longer than nonathletic controls, suggesting a benefit after …

[HTML][HTML] FGF23 promotes myocardial fibrosis in mice through activation of β-catenin

H Hao, X Li, Q Li, H Lin, Z Chen, J Xie, W Xuan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Fibroblast growth factor 23 (FGF23) has been reported to induce left ventricular
hypertrophy, but it remains unclear whether FGF23 plays a role in cardiac fibrosis. This study …

[HTML][HTML] Innate immune cells in pressure overload-induced cardiac hypertrophy and remodeling

X Liu, GP Shi, J Guo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Pressure overload and heart failure are among the leading causes of cardiovascular
morbidity and mortality. Accumulating evidence suggests that inflammatory cell activation …

[HTML][HTML] S100A8/A9 in myocardial infarction: a promising biomarker and therapeutic target

ZL Cai, Q Xie, T Hu, Q Yao, J Zhao, Q Wu… - Frontiers in cell and …, 2020 - frontiersin.org
Myocardial infarction (MI), the main cause of cardiovascular-related deaths worldwide, has
long been a hot topic because of its threat to public health. S100A8/A9 has recently attracted …

[HTML][HTML] Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis

V Kolur, B Vastrad, C Vastrad, S Kotturshetti… - BMC cardiovascular …, 2021 - Springer
Introduction Heart failure (HF) is a heterogeneous clinical syndrome and affects millions of
people all over the world. HF occurs when the cardiac overload and injury, which is a …

[HTML][HTML] Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice

J Yu, B Zhao, Q Pi, G Zhou, Z Cheng, C Qu, X Wang… - Respiratory …, 2023 - Springer
Background We have reported a positive correlation between S100 calcium-binding protein
(S100) A8/S100A9 and sepsis-induced lung damage before. However, limited knowledge …

Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A …

J Yu, Y Yang, Z Xu, C Lan, C Chen, C Li… - Circulation: Heart …, 2020 - Am Heart Assoc
Background: Long noncoding RNA (lncRNA) can regulate various physiological and
pathological processes through multiple molecular mechanisms in cis and in trans …

[HTML][HTML] S100 proteins in cardiovascular diseases

Y Zhou, Y Zha, Y Yang, T Ma, H Li, J Liang - Molecular Medicine, 2023 - Springer
Cardiovascular diseases have become a serious threat to human health and life worldwide
and have the highest fatality rate. Therefore, the prevention and treatment of cardiovascular …