FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity
K Benchoula, A Arya, IS Parhar, WE Hwa - European journal of …, 2021 - Elsevier
Glucose production and the consumption of high levels of carbohydrate increase the chance
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …
An insight into PI3k/Akt pathway and associated protein–protein interactions in metabolic syndrome: A recent update
K Verma, R Jaiswal, S Paliwal… - Journal of Cellular …, 2023 - Wiley Online Library
Akt, a known serine/threonine‐protein kinase B has been revealed to be an imperative
protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3 …
protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3 …
The emerging roles of chromogranins and derived polypeptides in atherosclerosis, diabetes, and coronary heart disease
T Watanabe - International Journal of Molecular Sciences, 2021 - mdpi.com
Chromogranin A (CgA), B (CgB), and C (CgC), the family members of the granin
glycoproteins, are associated with diabetes. These proteins are abundantly expressed in …
glycoproteins, are associated with diabetes. These proteins are abundantly expressed in …
[HTML][HTML] A prebiotic, short-chain fructo-oligosaccharides promotes peak bone mass and maintains bone mass in ovariectomized rats by an osteogenic mechanism
In preclinical studies, fructooligosaccharide (FOS) showed beneficial skeletal effects but its
effect on peak bone mass (PBM) and bone loss caused by estrogen (E2) deficiency has not …
effect on peak bone mass (PBM) and bone loss caused by estrogen (E2) deficiency has not …
[HTML][HTML] Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice
Aims To investigate the role of pancreastatin inhibitor (PSTi8) in lipid homeostasis and
insulin sensitivity in dexamethasone induced fatty liver disease associated type 2 diabetes …
insulin sensitivity in dexamethasone induced fatty liver disease associated type 2 diabetes …
Chromogranin A-derived peptides pancreastatin and catestatin: emerging therapeutic target for diabetes
Chromogranin A (ChgA) is an acidic pro-protein found in neuroendocrine organs,
pheochromocytoma chromaffin granules, and tumor cells. Proteolytic processing of ChgA …
pheochromocytoma chromaffin granules, and tumor cells. Proteolytic processing of ChgA …
Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress
Non-alcoholic fatty liver disease (NAFLD) is one of the most serious global public health
concerns. However, there are currently no effective drugs for treatment of this disease. Icariin …
concerns. However, there are currently no effective drugs for treatment of this disease. Icariin …
Ultrasonic–microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice
B Han, D Niu, T Wang, S An, Y Wang, X Chen, H Bi… - Food & function, 2020 - pubs.rsc.org
Triterpene acids, the main component of Corni Fructus, could improve diabetes mellitus, for
which the underlying hypoglycemic mechanism is still unclear, in patients. In this study, total …
which the underlying hypoglycemic mechanism is still unclear, in patients. In this study, total …
A novel resolution of diabetes: CC chemokine motif ligand 4 is a common target in different types of diabetes by protecting pancreatic islet cell and modulating …
TT Chang, LY Lin, JW Chen - Frontiers in Immunology, 2021 - frontiersin.org
Systemic inflammation is related to hyperglycemia in diabetes mellitus (DM). CC chemokine
motif ligand (CCL) 4 is upregulated in type 1 & type 2 DM patients. This study aimed to …
motif ligand (CCL) 4 is upregulated in type 1 & type 2 DM patients. This study aimed to …
Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis
DR Iyer, J Venkatraman, E Tanguy, N Vitale… - Cellular and Molecular …, 2023 - Springer
Chromogranin A (CHGA), a member of the granin family of proteins, has been an attractive
therapeutic target and candidate biomarker for several cardiovascular, neurological, and …
therapeutic target and candidate biomarker for several cardiovascular, neurological, and …