FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity

K Benchoula, A Arya, IS Parhar, WE Hwa - European journal of …, 2021 - Elsevier
Glucose production and the consumption of high levels of carbohydrate increase the chance
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …

An insight into PI3k/Akt pathway and associated protein–protein interactions in metabolic syndrome: A recent update

K Verma, R Jaiswal, S Paliwal… - Journal of Cellular …, 2023 - Wiley Online Library
Akt, a known serine/threonine‐protein kinase B has been revealed to be an imperative
protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3 …

The emerging roles of chromogranins and derived polypeptides in atherosclerosis, diabetes, and coronary heart disease

T Watanabe - International Journal of Molecular Sciences, 2021 - mdpi.com
Chromogranin A (CgA), B (CgB), and C (CgC), the family members of the granin
glycoproteins, are associated with diabetes. These proteins are abundantly expressed in …

[HTML][HTML] A prebiotic, short-chain fructo-oligosaccharides promotes peak bone mass and maintains bone mass in ovariectomized rats by an osteogenic mechanism

K Porwal, S Pal, C Kulkarni, P Singh, S Sharma… - Biomedicine & …, 2020 - Elsevier
In preclinical studies, fructooligosaccharide (FOS) showed beneficial skeletal effects but its
effect on peak bone mass (PBM) and bone loss caused by estrogen (E2) deficiency has not …

[HTML][HTML] Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice

AP Gupta, P Singh, R Garg, GR Valicherla… - Biomedicine & …, 2019 - Elsevier
Aims To investigate the role of pancreastatin inhibitor (PSTi8) in lipid homeostasis and
insulin sensitivity in dexamethasone induced fatty liver disease associated type 2 diabetes …

Chromogranin A-derived peptides pancreastatin and catestatin: emerging therapeutic target for diabetes

R Garg, A Agarwal, R Katekar, S Dadge, S Yadav… - Amino Acids, 2023 - Springer
Chromogranin A (ChgA) is an acidic pro-protein found in neuroendocrine organs,
pheochromocytoma chromaffin granules, and tumor cells. Proteolytic processing of ChgA …

Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress

P Yu, Z Qian, H Yang, T Xu, Y Dai, L Song… - European Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is one of the most serious global public health
concerns. However, there are currently no effective drugs for treatment of this disease. Icariin …

Ultrasonic–microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice

B Han, D Niu, T Wang, S An, Y Wang, X Chen, H Bi… - Food & function, 2020 - pubs.rsc.org
Triterpene acids, the main component of Corni Fructus, could improve diabetes mellitus, for
which the underlying hypoglycemic mechanism is still unclear, in patients. In this study, total …

A novel resolution of diabetes: CC chemokine motif ligand 4 is a common target in different types of diabetes by protecting pancreatic islet cell and modulating …

TT Chang, LY Lin, JW Chen - Frontiers in Immunology, 2021 - frontiersin.org
Systemic inflammation is related to hyperglycemia in diabetes mellitus (DM). CC chemokine
motif ligand (CCL) 4 is upregulated in type 1 & type 2 DM patients. This study aimed to …

Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis

DR Iyer, J Venkatraman, E Tanguy, N Vitale… - Cellular and Molecular …, 2023 - Springer
Chromogranin A (CHGA), a member of the granin family of proteins, has been an attractive
therapeutic target and candidate biomarker for several cardiovascular, neurological, and …