Deep learning in ophthalmology: the technical and clinical considerations

DSW Ting, L Peng, AV Varadarajan, PA Keane… - Progress in retinal and …, 2019 - Elsevier
The advent of computer graphic processing units, improvement in mathematical models and
availability of big data has allowed artificial intelligence (AI) using machine learning (ML) …

[HTML][HTML] Doppler optical coherence tomography

RA Leitgeb, RM Werkmeister, C Blatter… - Progress in retinal and …, 2014 - Elsevier
Abstract Optical Coherence Tomography (OCT) has revolutionized ophthalmology. Since its
introduction in the early 1990s it has continuously improved in terms of speed, resolution …

Discovery and clinical translation of novel glaucoma biomarkers

G Beykin, AM Norcia, VJ Srinivasan, A Dubra… - Progress in Retinal and …, 2021 - Elsevier
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …

[HTML][HTML] Endpoints for clinical trials in ophthalmology

L Schmetterer, H Scholl, G Garhöfer… - Progress in Retinal and …, 2023 - Elsevier
With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …

Retinal oximetry: metabolic imaging for diseases of the retina and brain

E Stefánsson, OB Olafsdottir, TS Eliasdottir… - Progress in retinal and …, 2019 - Elsevier
Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of
hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low …

Anatomical and functional changes in the retina in patients with Alzheimer's disease and mild cognitive impairment

S Szegedi, P Dal‐Bianco, E Stögmann… - Acta …, 2020 - Wiley Online Library
Purpose There is evidence that mild cognitive impairment (MCI) or Alzheimer's disease (AD)
is accompanied by alterations in the retina. The current study was performed to investigate …

[HTML][HTML] Ocular blood flow measurements in healthy white subjects using laser speckle flowgraphy

N Luft, PA Wozniak, GC Aschinger, K Fondi, AM Bata… - PloS one, 2016 - journals.plos.org
Purpose To assess the feasibility and reliability of Laser Speckle Flowgraphy (LSFG) to
measure ocular perfusion in a sample of healthy white subjects and to elucidate the age …

Assessment of flow dynamics in retinal and choroidal microcirculation

X Wei, PK Balne, KE Meissner, VA Barathi… - Survey of …, 2018 - Elsevier
Alterations in ocular blood flow have been implicated in mechanisms that lead to vision loss
in patients with various ocular disorders such as diabetic retinopathy, glaucoma, and age …

[HTML][HTML] Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy

K Fondi, PA Wozniak, K Howorka, AM Bata… - Diabetologia, 2017 - Springer
Aims/hypothesis The aim of this study was to compare retinal oxygen extraction in
individuals with diabetes with no or mild non-proliferative diabetic retinopathy and healthy …

Total retinal blood flow measurement by three beam Doppler optical coherence tomography

R Haindl, W Trasischker, A Wartak… - Biomedical optics …, 2016 - opg.optica.org
We present measurements of total retinal blood flow in healthy volunteers using a three
beam Doppler optical coherence tomography (D-OCT) technique. This technology has the …