Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-
molecule compounds starting from fragments binding weakly to targets. As FBDD exhibits …

In this review, a general introduction to fragment-based drug design and the underlying
concepts is given. General considerations and methodologies ranging from library …

Fragment-based drug discovery is a widely used strategy for drug design in both academic
and pharmaceutical industries. Although fragments can be linked to generate candidate …

Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach
to generate directed ligand libraries for macromolecular targets. In the absence of an …

Linking fragments to generate a focused compound library for a specific drug target is one of
the challenges in fragment-based drug design (FBDD). Hereby, we propose a new program …

The discovery of novel succinate dehydrogenase inhibitors (SDHIs) has attracted great
attention worldwide. Herein, a fragment recombination strategy was proposed to design new …

Imine synthesis has enjoyed a long history as the dynamic covalent reaction of choice for the
construction of purely covalent molecular architectures. In organic solvents, the formation of …

Conventional approaches to the synthesis of molecular knots and links mostly rely on metal
templation. We present here an alternative strategy that uses the hydrophobic effect to drive …

Photoisomerization provides a clean and efficient way of reversibly altering physical
properties of chemical systems and injecting energy into them. These effects have been …

The specific interactions responsible for molecular recognition play a crucial role in the
fundamental functions of biological systems. Mimicking these interactions remains one of the …