Cannabidiol as a therapeutic target: evidence of its neuroprotective and neuromodulatory function in Parkinson's disease

F Patricio, AA Morales-Andrade… - Frontiers in …, 2020 - frontiersin.org
The phytocannabinoids of Cannabis sativa L. have, since ancient times, been proposed as a
pharmacological alternative for treating various central nervous system (CNS) disorders …

Cannabis and its secondary metabolites: their use as therapeutic drugs, toxicological aspects, and analytical determination

J Gonçalves, T Rosado, S Soares, AY Simão… - Medicines, 2019 - mdpi.com
Although the medicinal properties of Cannabis species have been known for centuries, the
interest on its main active secondary metabolites as therapeutic alternatives for several …

[HTML][HTML] Inverted U-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life

AW Zuardi, NP Rodrigues, AL Silva… - Frontiers in …, 2017 - frontiersin.org
The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol
(CBD) in humans follows the same pattern of an inverted U-shaped dose-effect curve …

Cannabidiol as a promising strategy to treat and prevent movement disorders?

FF Peres, AC Lima, JEC Hallak, JA Crippa… - Frontiers in …, 2018 - frontiersin.org
Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating
conditions linked to oxidative stress and neurodegeneration. When available, the …

Cannabidiol (CBD) in cancer management

K O'Brien - Cancers, 2022 - mdpi.com
Simple Summary Cannabidiol (CBD) is one of the main constituents of the plant Cannabis
sativa. Surveys suggest that medicinal cannabis is popular amongst people diagnosed with …

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

ECD Gonçalves, GM Baldasso, MA Bicca, RS Paes… - Molecules, 2020 - mdpi.com
Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …

Genus Rauvolfia: A review of its ethnopharmacology, phytochemistry, quality control/quality assurance, pharmacological activities and clinical evidence

S Kumar, D Kumari, B Singh - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance The plants are from the genus Rauvolfia Plum. ex
L.(Apocynaceae), which is represented by 74 species with many synonyms, and distributed …

Cannabidiol: bridge between antioxidant effect, cellular protection, and cognitive and physical performance

G Jîtcă, BE Ősz, CE Vari, CM Rusz, A Tero-Vescan… - Antioxidants, 2023 - mdpi.com
The literature provides scientific evidence for the beneficial effects of cannabidiol (CBD), and
these effects extend beyond epilepsy treatment (eg, Lennox–Gastaut and Dravet …

Neurological aspects of medical use of cannabidiol

C Mannucci, M Navarra, F Calapai… - CNS & Neurological …, 2017 - ingentaconnect.com
Background: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis
devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based …

Is cannabidiol the ideal drug to treat non-motor Parkinson's disease symptoms?

JAS Crippa, JEC Hallak, AW Zuardi… - European archives of …, 2019 - Springer
Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by motor
symptoms such as bradykinesia, rest tremor, postural disturbances, and rigidity. PD is also …