Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic
functions. Evidence from experimental and clinical studies increasingly points to a …

After several decades of intensive efforts, safe injectable preparations capable of effectively
delivering O2 to tissues and removing CO2, ie, so-called blood substitutes, appear to be …

1.2. Background Fluorine NMR offers many attractive features, most notably detection
sensitivity approaching that of protons. 19 F has a nuclear spin I= 1/2, a gyromagnetic ratio …

The fluorine atom provides an exciting tool for diverse spectroscopic and imaging
applications using Magnetic Resonance. The organic chemistry of fluorine is widely …

The effect of the oxygen inhalation on relaxation times was evaluated in various tissues,
including the myocardium, liver, spleen, skeletal muscle, subcutaneous fat, bone marrow …

Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

A novel dual-mode contrast agent was formulated through the addition of an optical near
infrared (NIR) probe to a perfluorocarbon (PFC)-based 19F magnetic resonance imaging …

We have surveyed the sensitivity of the spin lattice relaxation rates of the 19F resonances of
several perfluorocarbons to changes in oxygen tension and temperature …

Preface t the end of the eighteenth century, Franz Joseph Gall postulated that the various
sensory, motor, and cognitive faculties of man arose from different organs and centers of the …

Purpose: We have developed an enhanced approach to measuring regional oxygen tension
(pO2) dynamics in tumors. The technique is demonstrated in a group of 8 Dunning prostate …