Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …
Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis
B Bartok, GS Firestein - Immunological reviews, 2010 - Wiley Online Library
Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant
therapeutic advances. The pathogenesis of RA is complex and includes many cell types …
therapeutic advances. The pathogenesis of RA is complex and includes many cell types …
Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
T Pap, A Korb-Pap - Nature Reviews Rheumatology, 2015 - nature.com
Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
Furin at the cutting edge: from protein traffic to embryogenesis and disease
G Thomas - Nature reviews Molecular cell biology, 2002 - nature.com
Furin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
T Nakagawa, S Shimizu, T Watanabe, O Yamaguchi… - Nature, 2005 - nature.com
Mitochondria play an important role in energy production, Ca2+ homeostasis and cell death.
In recent years, the role of the mitochondria in apoptotic and necrotic cell death has attracted …
In recent years, the role of the mitochondria in apoptotic and necrotic cell death has attracted …
[HTML][HTML] TGF-β and fibrosis in different organs—molecular pathway imprints
D Pohlers, J Brenmoehl, I Löffler, CK Müller… - … et Biophysica Acta (BBA …, 2009 - Elsevier
The action of transforming-growth-factor (TGF)-β following inflammatory responses is
characterized by increased production of extracellular matrix (ECM) components, as well as …
characterized by increased production of extracellular matrix (ECM) components, as well as …
ADAMTS‐4 and ADAMTS‐5: key enzymes in osteoarthritis
P Verma, K Dalal - Journal of cellular biochemistry, 2011 - Wiley Online Library
Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multi‐factorial, the cartilage …
articular cartilage. Although disease initiation may be multi‐factorial, the cartilage …
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
H Stanton, FM Rogerson, CJ East, SB Golub… - Nature, 2005 - nature.com
Aggrecan is the major proteoglycan in cartilage, endowing this tissue with the unique
capacity to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by …
capacity to bear load and resist compression. In arthritic cartilage, aggrecan is degraded by …
The role of interleukin 6 in the pathophysiology of rheumatoid arthritis
S Srirangan, EH Choy - Therapeutic advances in …, 2010 - journals.sagepub.com
Interleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of
rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients …
rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients …
The ADAMTS metalloproteinases
S Porter, IM Clark, L Kevorkian… - Biochemical …, 2005 - portlandpress.com
The ADAMTSs (ad isintegrin a nd m etalloproteinase with t hrombo s pondin motifs) are a
group of proteases that are found both in mammals and invertebrates. Since the prototype …
group of proteases that are found both in mammals and invertebrates. Since the prototype …