[HTML][HTML] Application of ligature-induced periodontitis in mice to explore the molecular mechanism of periodontal disease

P Lin, H Niimi, Y Ohsugi, Y Tsuchiya… - International journal of …, 2021 - mdpi.com
Periodontitis is an inflammatory disease characterized by the destruction of the
periodontium. In the last decade, a new murine model of periodontitis has been widely used …

[HTML][HTML] Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications

H Mulhall, O Huck, S Amar - Microorganisms, 2020 - mdpi.com
Periodontitis is an inflammatory disease associated with a dysbiosis of the oral flora
characterized by a chronic sustained inflammation leading to destruction of tooth-supporting …

[HTML][HTML] Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment

C Ni, J Zhou, N Kong, T Bian, Y Zhang, X Huang… - Biomaterials, 2019 - Elsevier
The regeneration of lost periodontal apparatus in periodontitis treatment remains a clinical
challenge due to the limited regenerative capacity of cementum, periodontal ligament and …

[HTML][HTML] Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice

JS Suh, S Kim, KI Boström, CY Wang, RH Kim… - International journal of …, 2019 - nature.com
Growing evidence suggests close associations between periodontitis and atherosclerosis.
To further understand the pathological relationships of these associations, we developed …

[HTML][HTML] Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner

M Xie, Q Tang, S Yu, J Sun, F Mei, J Zhao… - International Journal of …, 2020 - nature.com
Cardiovascular disease is still the leading cause of mortality worldwide. Vascular
endothelial dysfunction is viewed as the initial step of most cardiovascular diseases. Many …

[HTML][HTML] Human β-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages

D Cui, J Lyu, H Li, L Lei, T Bian, L Li, F Yan - Molecular Immunology, 2017 - Elsevier
Abstract Human β-defensin 3 (hBD3) is a cationic peptide with immunomodulatory effects on
both innate and acquired immune responses. Periodontitis, an inflammatory disease that …

[HTML][HTML] B cell activating factor regulates periodontitis development by suppressing inflammatory responses in macrophages

L Wang, T Zhang, Z Zhang, Z Wang, YJ Zhou, Z Wang - BMC oral health, 2021 - Springer
Background B cell activating factor (BAFF) is a member of the tumor necrosis factor (TNF)
superfamily with immunomodulatory effects on both innate and adaptive immune responses …

[HTML][HTML] Cross-sectional analysis of the association between periodontitis and cardiovascular disease using the Korean genome and epidemiology study data

SH Byun, S Lee, SH Kang, HG Choi… - International Journal of …, 2020 - mdpi.com
This cross-sectional study aimed to evaluate the association between periodontitis and
cardiovascular disease (CVD) by reviewing and discussing the role of the oral microbiome …

Apolipoprotein E, periodontal disease and the risk for atherosclerosis: a review

LC Pereira, JCR Nascimento, JMC Rêgo… - Archives of Oral …, 2019 - Elsevier
The association between cardiovascular and periodontal diseases is characterized by
chronic inflammatory processes, with a high prevalence worldwide and complex genetic …

The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling

L Jiang, XQ Chen, MJ Gao, W Lee… - Journal of Cellular …, 2019 - Wiley Online Library
Periodontitis, an oral inflammatory disease caused by periodontal pathogen infection, is the
most prevalent chronic inflammatory disease and a major burden on healthcare. The TAM …