Neurodegeneration is a phenomenon that occurs in the central nervous system through the
hallmarks associating the loss of neuronal structure and function. Neurodegeneration is …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Type 2 diabetes with obesity-related insulin resistance as the main manifestation is
associated with an increased risk of cognitive impairment. Adipose tissue plays an important …

Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …

Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

There is strong evidence that diabetes mellitus increases the risk of cognitive impairment
and dementia. Insulin signaling dysregulation and small vessel disease in the base of …

Diabetes is a leading cause of morbidity and mortality. The global burden of diabetes is
rising because of increased obesity and population ageing. Although preventive and …

Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …