Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Mitochondria with structural and functional integrity are essential for maintaining
mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart
failure, but it remains elusive whether there is a common pathway to induce both events …

Aging is broadly defined as the functional decline that occurs in all body systems. The
accumulation of senescent cells is considered a hallmark of aging and thought to contribute …

Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and experimental
studies have associated BAT activity with protection against obesity and metabolic diseases …

Brown and beige adipocytes expend chemical energy to produce heat and are therefore
important in regulating body temperature and body weight. Brown adipocytes develop in …