Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Microorganisms form diverse multispecies communities in various ecosystems. The high
abundance of fungal and bacterial species in these consortia results in specific …

Medicinal Natural Products, Second Edition is a comprehensive guide providing information
on all classes of natural products in medicine. It builds upon fundamental chemical …

Fungi produce an impressive array of secondary metabolites (SMs) including mycotoxins,
antibiotics and pharmaceuticals. The genes responsible for their biosynthesis, export, and …

Marine sponges often contain diverse and abundant microbial communities, including
bacteria, archaea, microalgae, and fungi. In some cases, these microbial associates …

Covering: up to June 2006We review the literature on the enzymes, genes, and whole gene
clusters underlying natural product biosyntheses and their regulation in filamentous fungi …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical
advance has ever had the same impact in the clinical practise. The fungus Penicillium …

Antibiotic natural products are ancient and so is resistance. Consequently, environmental
bacteria harbor numerous and varied antibiotic resistance elements. Nevertheless, despite …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …