Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
SW Awwad, A Serrano-Benitez, JC Thomas… - … Reviews Molecular Cell …, 2023 - nature.com
All organisms possess molecular mechanisms that govern DNA repair and associated DNA
damage response (DDR) processes. Owing to their relevance to human disease, most …
damage response (DDR) processes. Owing to their relevance to human disease, most …
TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Reprogramming to recover youthful epigenetic information and restore vision
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Abstract N 6-methyladenosine (m6A), the most prevalent internal RNA modification on
mammalian messenger RNAs, regulates the fates and functions of modified transcripts …
mammalian messenger RNAs, regulates the fates and functions of modified transcripts …
Editing DNA methylation in the mammalian genome
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …
expression networks in many biological processes. However, investigation of the functions …
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
RNA modifications regulate a variety of cellular processes including DNA repair. The RNA
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
DNA methylation and regulation of gene expression: Guardian of our health
GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
Positive controls in adults and children support that very few, if any, new neurons are born in the adult human hippocampus
Adult hippocampal neurogenesis was originally discovered in rodents. Subsequent studies
identified the adult neural stem cells and found important links between adult neurogenesis …
identified the adult neural stem cells and found important links between adult neurogenesis …
DNA methylation: an epigenetic mark of cellular memory
M Kim, J Costello - Experimental & molecular medicine, 2017 - nature.com
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
Physical exercise as an epigenetic modulator of brain plasticity and cognition
J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …
function, the effects of which can last for considerable time. An emerging line of scientific …