The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
A Szallasi, DN Cortright, CA Blum, SR Eid - Nature reviews Drug …, 2007 - nature.com
The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
[图书][B] Pharmacological actions of cannabinoids
RG Pertwee - 2005 - Springer
Pharmacological Actions of Cannabinoids | SpringerLink Skip to main content Advertisement
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice
MC Marrone, A Morabito, M Giustizieri… - Nature …, 2017 - nature.com
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …
Anandamide and vanilloid TRPV1 receptors
RA Ross - British journal of pharmacology, 2003 - Wiley Online Library
A large body of evidence now exists to substantiate that the endocannabinoid, anandamide,
activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a …
activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a …
Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions
YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
The transient receptor potential TRPV1 is a nonselective cation channel that mediates pain
sensations and is commonly activated by a wide variety of exogenous and endogenous …
sensations and is commonly activated by a wide variety of exogenous and endogenous …
Thermosensation and pain
M Tominaga, MJ Caterina - Journal of neurobiology, 2004 - Wiley Online Library
We feel a wide range of temperatures spanning from cold to heat. Within this range,
temperatures over about 43° C and below about 15° C evoke not only a thermal sensation …
temperatures over about 43° C and below about 15° C evoke not only a thermal sensation …
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels
have been proposed to act as metabotropic and ionotropic receptors, respectively, for two …
have been proposed to act as metabotropic and ionotropic receptors, respectively, for two …
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors
The endogenous cannabinoid system has been shown to play a crucial role in controlling
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …
Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain
The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli,
including capsaicin, acid, and high temperature. It can also be activated by endogenous …
including capsaicin, acid, and high temperature. It can also be activated by endogenous …