Oxidized bases in the mammalian genome, which are invariably mutagenic due to their
mispairing property, are continuously induced by endogenous reactive oxygen species and …

DNA repair systems play a critical role in maintaining the integrity and stability of the
genome, which mainly include base excision repair (BER), nucleotide excision repair (NER) …

Single-strand breaks (SSBs) are the most common type of oxidative DNA damage and they
are related to aging and many genetic diseases. The scaffold protein for repair of SSBs …

Colorectal cancer (CRC) is the third most common carcinoma worldwide. Despite the
progress in screening and treatment, CRC remains a leading cause of cancer-related …

Background: Colorectal cancer is the third most common cancer in both men and women in
the world andthe second leading cause of cancer-related deaths. The incidence of …

Background: Non-synonymous polymorphisms in XRCC1 hase been shown to reduce
effectiveness of DNA repair and be associated with risk of certain cancers. In this study we …

This study presents the first results of a molecular-genetic study of colorectal cancer (CRC)
in Kazakhstan. Blood samples were collected from patients diagnosed with rectal or colon …

X-ray repair cross-complementing group 1 (XRCC1), a DNA repair enzyme, plays a crucial
role in the base excision repair by generating a single nucleotide repair patch. It has been …

Background: Genetic polymorphisms in DNA repair genes may influence individual variation
in DNA repair capacity, which may be associated with risk of developing cancer. For …

Abstract The Arg194Trp polymorphism in the X-ray cross-complementing group 1 (XRCC1)
had been implicated in cancer susceptibility. The previous published data on the association …