Oxidative stress is implicated as one of the major underlying mechanisms behind many
acute and chronic diseases, and involved in normal aging. However, the measurement of …

Isoprostanes, are a novel group of prostaglandin-like compounds that are biosynthesised
from esterified polyunsaturated fatty acid (PUFA) through a non-enzymatic free radical …

Objectives: Cardiac arrest is associated with morbidity and mortality because of cerebral
ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation …

Electrophysiologic techniques and molecular markers of brain injury allow the accurate
assessment and prognostication of long-term outcome in cardiac arrest survivors. In …

Prostaglandin F2α (PGF2α), a foremost stable vasoactive cyclooxygenase (COX)‐catalyzed
prostaglandin, regulates a number of key physiological functions such as luteolysis, ovarian …

Ischemic brain injury inflicted by stroke and cardiac arrest ranks among the leading causes
of death and long-term disability in the United States. The brain consumes large amounts of …

Discovery of the F2-isoprostanes, a group of prostaglandin F2α-like compounds
biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel …

The endothelium is a viable target for injury, repair and cellular modulation. Because of its
vast extension and active metabolic status of producing mediators for vasomotor tone …

Objectives: Cardiac arrest etiology may be an important source of between-patient
heterogeneity, but the impact of etiology on organ injury is unknown. We tested the …

The prostanoids, a naturally occurring subclass of eicosanoids, are lipid mediators
generated through oxidative pathways from arachidonic acid. These cyclooxygenase …