Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a
propensity for increased levels following toxic insult. Although more than 20 base lesions …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

Cold Spring Harbor Symposia on Quantitative Biology, Volume LXV.© 2000 Cold Spring
Harbor Laboratory Press 0-87969-605-2/00. 127 bile glycosyl bond of 7 …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

The DNA damage response is a hierarchical process. DNA damage is detected by sensor
proteins such as the MRN complex that transmit the information to transducer proteins such …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

The study of DNA oxidation has progressed from an exploratory phase, during which its
basic biochemistry was established, into a field branching out into numerous areas. Early …

Abstract The XPC-HR23B complex is specifically involved in global genome but not
transcription-coupled nucleotide excision repair (NER). Its function is unknown. Using a …

▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …