The past, present, and future of antibiotics

MA Cook, GD Wright - Science Translational Medicine, 2022 - science.org
Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

[HTML][HTML] Shaping the future of probiotics and prebiotics

M Cunningham, MA Azcarate-Peril, A Barnard… - Trends in …, 2021 - cell.com
Recent and ongoing developments in microbiome science are enabling new frontiers of
research for probiotics and prebiotics. Novel types, mechanisms, and applications currently …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

[HTML][HTML] Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics

J Murugaiyan, PA Kumar, GS Rao, K Iskandar… - Antibiotics, 2022 - mdpi.com
Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR),
continues to evolve and spread beyond all boundaries. As a result, infectious diseases have …

Antimicrobial resistance in ESKAPE pathogens

DMP De Oliveira, BM Forde, TJ Kidd… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

[HTML][HTML] A bottom-up view of antimicrobial resistance transmission in developing countries

OO Ikhimiukor, EE Odih, P Donado-Godoy… - Nature …, 2022 - nature.com
Antimicrobial resistance (AMR) is tracked most closely in clinical settings and high-income
countries. However, resistant organisms thrive globally and are transmitted to and from …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

[HTML][HTML] A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …