Accumulation of reactive oxygen and chlorine species (RO/CS) is generally regarded to be a
toxic and highly undesirable event, which serves as contributing factor in aging and many …

Proper localization of membrane proteins is essential for the function of biological
membranes and for the establishment of organelle identity within a cell. Molecular …

Hundreds of tail-anchored proteins, including soluble N-ethylmaleimide-sensitive factor
attachment receptors (SNAREs) involved in vesicle fusion, are inserted post-translationally …

Due to their topology tail-anchored (TA) proteins must target to the membrane independently
of the co-translational route defined by the signal sequence recognition particle (SRP), its …

Tail-anchored (TA) proteins are a physiologically important class of membrane proteins
targeted to the endoplasmic reticulum by the conserved guided-entry of TA proteins (GET) …

BCL2-associated athanogene cochaperone 6 (Bag6) plays a central role in cellular
homeostasis in a diverse array of processes and is part of the heterotrimeric Bag6 complex …

Proteins targeted to the secretory pathway start their intracellular journey by being
transported across biological membranes such as the endoplasmic reticulum (ER). A central …

BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in
a variety of seemingly unrelated physiological and pathological processes, such as …

Tail-anchored (TA) proteins are inserted into membranes post-translationally through a C-
terminal transmembrane domain (TMD). The PEX19 protein binds peroxisome TA proteins …

Tail-anchored (TA) membrane proteins, accounting for roughly 2% of proteomes, are
primarily targeted posttranslationally to the endoplasmic reticulum membrane by the guided …