Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

A central dogma of mammalian reproductive biology is that the size of the primordial follicle
pool represents reproductive capacity in females. The assembly of the primordial follicle …

In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment.
An alternative to commonly used ovarian hyperstimulation can become extracorporeal …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which
prevents their precocious maturation. We show that mouse mural granulosa cells, which line …

Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …