The epigenetic control of the transposable element life cycle in plant genomes and beyond
Within the life cycle of a living organism, another life cycle exists for the selfish genome
inhabitants, which are called transposable elements (TEs). These mobile sequences invade …
inhabitants, which are called transposable elements (TEs). These mobile sequences invade …
[HTML][HTML] Human-specific NOTCH2NL genes affect notch signaling and cortical neurogenesis
Genetic changes causing brain size expansion in human evolution have remained elusive.
Notch signaling is essential for radial glia stem cell proliferation and is a determinant of …
Notch signaling is essential for radial glia stem cell proliferation and is a determinant of …
High-resolution comparative analysis of great ape genomes
ZN Kronenberg, IT Fiddes, D Gordon, S Murali… - Science, 2018 - science.org
INTRODUCTION Understanding the genetic differences that make us human is a long-
standing endeavor that requires the comprehensive discovery and comparison of all forms …
standing endeavor that requires the comprehensive discovery and comparison of all forms …
LINE‐1 retrotransposons in healthy and diseased human brain
ABSTRACT Long interspersed element‐1 (LINE‐1 or L1) is a transposable element with the
ability to self‐mobilize throughout the human genome. The L1 elements found in the human …
ability to self‐mobilize throughout the human genome. The L1 elements found in the human …
LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion
F Marasca, S Sinha, R Vadalà, B Polimeni, V Ranzani… - Nature …, 2022 - nature.com
How gene expression is controlled to preserve human T cell quiescence is poorly
understood. Here we show that non-canonical splicing variants containing long interspersed …
understood. Here we show that non-canonical splicing variants containing long interspersed …
[HTML][HTML] Human-specific regulation of neural maturation identified by cross-primate transcriptomics
Unique aspects of human behavior are often attributed to differences in the relative size and
organization of the human brain: these structural aspects originate during early …
organization of the human brain: these structural aspects originate during early …
Evolutionary conservation in noncoding genomic regions
NA Leypold, MR Speicher - Trends in Genetics, 2021 - cell.com
Humans may share more genomic commonalities with other species than previously
thought. According to current estimates,~ 5% of the human genome is functionally …
thought. According to current estimates,~ 5% of the human genome is functionally …
SAFB restricts contact domain boundaries associated with L1 chimeric transcription
Y Hong, L Bie, T Zhang, X Yan, G Jin, Z Chen, Y Wang… - Molecular Cell, 2024 - cell.com
Summary Long interspersed element-1 (LINE-1 or L1) comprises 17% of the human
genome, continuously generates genetic variations, and causes disease in certain cases …
genome, continuously generates genetic variations, and causes disease in certain cases …
ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription
C Yu, X Lei, F Chen, S Mao, L Lv, H Liu, X Hu… - Nature …, 2022 - nature.com
Transposable elements (TEs) through evolutionary exaptation have become an integral part
of the human genome, offering ample regulatory sequences and shaping chromatin 3D …
of the human genome, offering ample regulatory sequences and shaping chromatin 3D …
RNAs, phase separation, and membrane‐less organelles: Are post‐transcriptional modifications modulating organelle dynamics?
A Drino, MR Schaefer - BioEssays, 2018 - Wiley Online Library
Membranous organelles allow sub‐compartmentalization of biological processes. However,
additional subcellular structures create dynamic reaction spaces without the need for …
additional subcellular structures create dynamic reaction spaces without the need for …