Recent advances in bioprocessing application of membrane chromatography

V Orr, L Zhong, M Moo-Young, CP Chou - Biotechnology advances, 2013 - Elsevier
Compared to traditional chromatography using resins in packed-bed columns, membrane
chromatography is a relatively new and immature bioseparation technology based on the …

The transition from resin chromatography to membrane adsorbers for protein separations at industrial scale

Y Qu, I Bekard, B Hunt, J Black, L Fabri… - Separation & …, 2024 - Taylor & Francis
Membrane adsorbers (MA) are emerging as alternative unit operations in high-value protein
separation due to their many benefits, including short residence times, low pressure drop …

Towards next generation high throughput ion exchange membranes for downstream bioprocessing: A review

X Yang, A Merenda, ALA Riyadh, LF Dumée… - Journal of Membrane …, 2022 - Elsevier
Membrane chromatography is recognised as a potential solution to streamline downstream
processing for protein purification, where ion exchange membrane chromatography (IEMC) …

An overview of mechanistic modeling of liquid chromatography

LK Shekhawat, AS Rathore - Preparative biochemistry and …, 2019 - Taylor & Francis
Liquid chromatography is considered to be the bottleneck for purification of therapeutic
proteins. Development and optimization of chromatography process is a cumbersome …

[HTML][HTML] Why device design is crucial for membrane adsorbers

F Hagemann, D Wypysek, K Baitalow… - Journal of …, 2022 - Elsevier
In preparative chromatography, a uniform flow distribution through the chromatography
device is essential to get an effective ligand utilization and a breakthrough curve that is as …

Membrane processes for whey proteins separation and purification. A review

R Aguero, E Bringas, MF San Roman… - Current Organic …, 2017 - ingentaconnect.com
Background: Whey is a valuable by-product obtained from cheese manufacture and
employed as a source of proteins that present remarkable potential in food or …

Convection rather than diffusion for fast efficient mRNA vaccine purification

R Banik, TG Neuman, Z Hao, M Al Sharabati… - Separation and …, 2025 - Elsevier
In the rush to produce mRNA vaccines and ensure integrity and purity, capital-intensive
purification steps were used, typically involving slow diffusion-driven, inefficient, and costly …

A z2 laterally-fed membrane chromatography device for fast high-resolution purification of biopharmaceuticals

R Ghosh, G Chen, R Roshankhah, U Umatheva… - … of Chromatography A, 2020 - Elsevier
We examine the use of az 2 flow distribution and collection feature for enhancing the
separation efficiency of a laterally-fed membrane chromatography (or LFMC) device. The …

Study of the adsorption of proteins on stainless steel surfaces using QCM-D

N Chandrasekaran, S Dimartino, CJ Fee - Chemical Engineering Research …, 2013 - Elsevier
Stainless steel is widely used in a number of industries, ranging from food and dairy to
pharmaceuticals. However, fouling associated with protein adsorption constitutes a main …

Predicting steroid hormone removal in a thin activated carbon layer coupled with ultrafiltration

M Tagliavini, MN Nguyen, AI Schäfer - Chemical Engineering Journal, 2023 - Elsevier
Ultrafiltration coupled with a thin polymer-based activated carbon (PBSAC) layer promises to
tackle the challenge of estrogenic micropollutants in water. The proposed drinking water …