Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In
mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection …

The intracellular compartment harboring Toxoplasma gondii satisfies the parasite's
nutritional needs for rapid growth in mammalian cells. We demonstrate that the …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Despite the many decades of use of most of the current trypanocides, we know little of their
mode of action. This may in part be because most of these will act on multiple targets once …

Publisher Summary Although there are several reports of Leishmania parasitizing cells other
than macrophages or even existing extracellularly in mammalian tissue, it is generally …

The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause
important diseases in humans. These include Trypanosoma brucei (the causative agent of …

The dense coat of glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein
(VSG) covering parasitic African trypanosomes is essential for survival in mammalian hosts …

African trypanosomes present several features of interest to cell biologists. These include: a
repressible single mitochondrion with a large mass of mitochondrial DNA, the kinetoplast; a …