The diagnosis of methemoglobinemia should be considered in patients presenting with
cyanosis and hypoxia. A variety of frequently used medications are capable of inducing …

Objective: To present a comprehensive review of dapsone-induced methemoglobinemia
and its management. Data Sources: Literature retrieval was accessed through MEDLINE …

BACKGROUND: Dapsone, used for Pneumocystis jiroveci (PCP) prophylaxis, is associated
with increased risk of methemoglobinemia. Absence of cytochrome b5 reductase enzyme …

Anemia, leukopenia, thrombocytopenia, as well as pancytopenias can be seen following
solid organ transplant. Varying patterns of cytopenia can be seen based on the drugs used …

Primary brain tumor patients have multiple risk factors for Pneumocystis jiroveci and may
require prophylaxis with TMP-SMZ or dapsone. Although dapsone is generally safe and …

Background: Without prophylaxis, Pneumocystis jiroveci pneumonia (PCP) develops in 5%–
15% of pediatric hematopoietic stem cell transplant (HCT) patients with mortality above 50 …

Dapsone (4, 4′-diaminodiphenylsulfone; DDS) is a sulfone antimicrobial used to treat
leprosy, malaria, and inflammatory dermatoses and to prevent and treat opportunistic …

Methemoglobinemia occurs when hemoglobin is oxidized to form methemoglobin (MetHb)
rendering it incapable of oxygen transport and leading to tissue hypoxia. Typically …

Individuals with hematologic malignancies are at an increased risk for Pneumocystis jiroveci
pneumonia (PJP) due to immune suppression. Trimethoprim-sulfamethoxazole (TMP-SMX) …

Dapsone is an antibacterial medication used as an alternative to the first-line therapy
(sulfamethoxazole-trimethoprim) for Pneumocystis pneumonia prophylaxis …