Targeting transcription factors for cancer treatment
M Lambert, S Jambon, S Depauw… - Molecules, 2018 - mdpi.com
Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …
which they account for about 20% of all oncogenes identified so far. For long time, with the …
[PDF][PDF] An overview of recent advances in duplex DNA recognition by small molecules
As the carrier of genetic information, the DNA double helix interacts with many natural
ligands during the cell cycle, and is amenable to such intervention in diseases such as …
ligands during the cell cycle, and is amenable to such intervention in diseases such as …
“Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes
Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …
Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia
JR Rivas, Y Liu, SS Alhakeem, JM Eckenrode, F Marti… - Leukemia, 2021 - nature.com
T-cell dysfunction is a hallmark of B-cell Chronic Lymphocytic Leukemia (CLL), where CLL
cells downregulate T-cell responses through regulatory molecules including programmed …
cells downregulate T-cell responses through regulatory molecules including programmed …
Targeting DNA minor groove by hybrid molecules as anticancer agents
S Nekkanti, R Tokala… - Current Medicinal …, 2017 - ingentaconnect.com
Agents which can recognize and bind specific sequences of DNA offer selective therapy
through the modulation of specific transcription factors or genes. Recently, there has been …
through the modulation of specific transcription factors or genes. Recently, there has been …
The antitumor antibiotic mithramycin: new advanced approaches in modification and production
J Kormanec, R Novakova, D Csolleiova… - Applied Microbiology …, 2020 - Springer
The aureolic acid-type polyketide mithramycin (MTM) has a remarkable cytotoxicity against a
variety of human tumors and has been used for the treatment of several types of cancer …
variety of human tumors and has been used for the treatment of several types of cancer …
A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding
The structure of the DNA duplex is arguably one of the most important biological structures
elucidated in modern history. DNA duplex structure is closely associated with essential …
elucidated in modern history. DNA duplex structure is closely associated with essential …
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis
T Liu, L Xia, Y Yao, C Yan, Y Fan, B Gajendran… - Cell Death & …, 2019 - nature.com
The ETS transcription factor Fli-1 controls the expression of genes involved in
hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation of Fli-1 …
hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation of Fli-1 …
Mithramycin and its analogs: Molecular features and antitumor action
J Portugal - Pharmacology & therapeutics, 2024 - Elsevier
The antitumor antibiotic mithramycin A (MTA) binds to G/C-rich DNA sequences in the
presence of dications. MTA inhibits transcription regulated by the Sp1 transcription factor …
presence of dications. MTA inhibits transcription regulated by the Sp1 transcription factor …
Mithramycin and analogs for overcoming cisplatin resistance in ovarian cancer
Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable.
Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis …
Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis …