The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review
BD Fontana, NJ Mezzomo, AV Kalueff… - Experimental …, 2018 - Elsevier
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …
genetic tractability, molecular/physiological conservation, small body size, ease of …
Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease
SH Barage, KD Sonawane - Neuropeptides, 2015 - Elsevier
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various
therapeutic approaches are being used to improve the cholinergic neurotransmission, but …
therapeutic approaches are being used to improve the cholinergic neurotransmission, but …
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
A hallmark of Alzheimer's disease (AD) is the aggregation of β-amyloid peptides (Aβ) into
amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the …
amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the …
[HTML][HTML] Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1 …
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1 …
Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum
D Campion, C Dumanchin, D Hannequin… - The American Journal of …, 1999 - cell.com
To determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal
dominant forms of EOAD (ADEOAD), we performed a population-based study in the city of …
dominant forms of EOAD (ADEOAD), we performed a population-based study in the city of …
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
PR Turner, K O'Connor, WP Tate, WC Abraham - Progress in neurobiology, 2003 - Elsevier
Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2),
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …
[HTML][HTML] Skeletal and CNS defects in Presenilin-1-deficient mice
Abstract Presenilin-1 (PS1) is the major gene responsible for early-onset familial Alzheimer's
disease (FAD). To understand the normal function of PS1, we have generated a targeted …
disease (FAD). To understand the normal function of PS1, we have generated a targeted …
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to
mutations in two related genesPS1 and PS2, located on chromosome 14 and 1 …
mutations in two related genesPS1 and PS2, located on chromosome 14 and 1 …
The genetics of Alzheimer's disease
Alzheimer's disease (AD) is a complex and heterogeneous neurodegenerative disorder,
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …