Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …
Macrophage: a potential target on cartilage regeneration
Cartilage lesions and osteoarthritis (OA) presents an ever-increasing clinical and
socioeconomic burden. Synovial inflammation and articular inflammatory environment are …
socioeconomic burden. Synovial inflammation and articular inflammatory environment are …
Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
L Jenkins, U Jungwirth, A Avgustinova, M Iravani… - Cancer research, 2022 - AACR
Immune-checkpoint blockade (ICB) promotes antitumor immune responses and can result in
durable patient benefit. However, response rates in breast cancer patients remain modest …
durable patient benefit. However, response rates in breast cancer patients remain modest …
The molecular interaction of collagen with cell receptors for biological function
J Elango, C Hou, B Bao, S Wang… - Polymers, 2022 - mdpi.com
Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …
biological functions in normal physiology. Recently, collagen from non-human sources has …
Therapy for fibrotic diseases: nearing the starting line
SL Friedman, D Sheppard, JS Duffield… - Science translational …, 2013 - science.org
Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic …
common feature of chronic tissue injury. Pulmonary fibrosis, renal fibrosis, and hepatic …
Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells
Q Wang, Y Liu, H Wang, P Jiang, W Qian… - Nature …, 2022 - nature.com
Abstract DNA methyltransferase 3 A (DNMT3A) is the most frequently mutated gene in acute
myeloid leukemia (AML). Although chemotherapy agents have improved outcomes for …
myeloid leukemia (AML). Although chemotherapy agents have improved outcomes for …
Extracellular matrix dynamics in development and regenerative medicine
The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation,
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …
[HTML][HTML] Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics
D Rodríguez, CJ Morrison, CM Overall - Biochimica et Biophysica Acta …, 2010 - Elsevier
The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …
associated with the degradation and turnover of most of the components of the extracellular …
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
CM Overall, O Kleifeld - Nature Reviews Cancer, 2006 - nature.com
The matrix metalloproteinases (MMPs) mediate homeostasis of the extracellular
environment. They have multiple signalling activities that are commonly altered during …
environment. They have multiple signalling activities that are commonly altered during …
M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway
Tissue remodeling processes critically depend on the timely removal and remodeling of
preexisting collagen scaffolds. Nevertheless, many aspects related to the turnover of this …
preexisting collagen scaffolds. Nevertheless, many aspects related to the turnover of this …