The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …

Opioid receptors of the μ-, δ-and κ-subtypes mediate the potent analgesic and addictive
actions of opioid drugs. They also regulate responses to pain, stress and emotions when …

Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …

Mu opioid receptors mediate positive reinforcement following direct (morphine) or indirect
(alcohol, cannabinoids, nicotine) activation, and our understanding of mu receptor function …

Buprenorphine, an opioid with mixed agonist-antagonist activity at classical opioid
receptors, has been approved recently for the treatment of opioid dependency …

Identification of the enigmatic nociceptin/orphanin FQ peptide (N/OFQ) in 1995 represented
the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ …

The advance in our understanding of the biogenesis of various endogenous opioid
peptides, their anatomical distribution, and the characteristics of the multiple receptors with …

Abstract Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized
in 1995. The generation of specific agonists, antagonists and receptor deficient mice and …