High cholesterol is a major risk factor for cardiovascular disease. Currently, no drug lowers
cholesterol through directly promoting cholesterol excretion. Human genetic studies have …

The breast and ovarian cancer susceptibility gene (BRCA1) is a tumor suppressor whose
mutation has been associated with the development of breast, ovarian and, probably, other …

Breast cancer is the most prevalent cancer in women. Metabolic abnormalities, particularly
increased lipid synthesis and uptake, impact the onset and progression of the disease …

Herein, we report the synthesis of mixed-ligand Cu (II) complexes of metformin and
ciprofloxacin drugs together with 1, 10-phenanthroline as a co-ligand. The synthesized …

Background Breast cancer chemotherapy with high dose alkylating agents is severely
limited by their collateral toxicity to crucial normal tissues such as immune and gut cells …

Tobacco smoking (TS) is implicated in lung cancer (LC) progression through the
development of metabolic syndrome. However, direct evidence linking metabolic syndrome …

The addition of hydrogen peroxide (H2O2) to cultured cells is widely used as a method to
modulate redox-regulated cellular pathways, including the induction of programmed cell …

An in vitro study was designed to evaluate the effects of photobiomodulation (PBM) with 915-
nm diode laser on human gingival fibroblast (HGF) cells under hyperglycemic condition. The …

The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA
methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein …

Numerous ancient cultures already knew the beneficial effects of physical heating of the
organism, using hot water baths, hot sand, or hot steam. In the seventeenth century, the …