Ebola virus disease

ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

Tracking virus outbreaks in the twenty-first century

ND Grubaugh, JT Ladner, P Lemey, OG Pybus… - Nature …, 2019 - nature.com
Emerging viruses have the potential to impose substantial mortality, morbidity and economic
burdens on human populations. Tracking the spread of infectious diseases to assist in their …

Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks

AK Keita, FR Koundouno, M Faye, A Düx, J Hinzmann… - Nature, 2021 - nature.com
Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the
country faced a new outbreak—between 14 February and 19 June 2021—near the …

[HTML][HTML] Why does viral RNA sometimes persist after recovery from acute infections?

DE Griffin - PLoS biology, 2022 - journals.plos.org
DNA viruses often persist in the body of their host, becoming latent and recurring many
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …

Towards a genomics-informed, real-time, global pathogen surveillance system

JL Gardy, NJ Loman - Nature Reviews Genetics, 2018 - nature.com
Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

Effects of COVID-19 and mRNA vaccines on human fertility

F Chen, S Zhu, Z Dai, L Hao, C Luan, Q Guo… - Human …, 2022 - academic.oup.com
ABSTRACT The coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of …

Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California

X Deng, W Gu, S Federman, L Du Plessis, OG Pybus… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with> 365,000 cases in …

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and …

D Siegel, HC Hui, E Doerffler, MO Clarke, K Chun… - 2017 - ACS Publications
The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history
with over 28,000 cases, resulting in> 11,000 deaths including> 500 healthcare workers. A …

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

TK Warren, R Jordan, MK Lo, AS Ray, RL Mackman… - Nature, 2016 - nature.com
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the
number of cases and fatalities, geographic distribution, and number of nations affected …

Real-time, portable genome sequencing for Ebola surveillance

J Quick, NJ Loman, S Duraffour, JT Simpson, E Severi… - Nature, 2016 - nature.com
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for
over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is …