Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

The last decade has provided a virtual explosion of data on the molecular biology and
function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been …

Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several
tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological …

Bone fragility is a major health concern, as the increased risk of bone fractures has
devastating outcomes in terms of mortality, decreased autonomy, and healthcare costs …

Osteocytes, the most abundant cells in bone, have been long postulated to detect and
respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts …

Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

Vital osteocytes have been well known to function as an important orchestrator in the
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …