Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …
coding transcripts with unknown function. There are several types of non-coding linear …
Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …
of genes, is required for normal development, and its disruption leads to human disease …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
Target identification among known drugs by deep learning from heterogeneous networks
Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …
and affordable approaches for effective treatment of human diseases is challenging. Here …
R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a mutation or
deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited …
deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited …
Genomic imprinting in mammals
DP Barlow, MS Bartolomei - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Genomic imprinting affects a subset of genes in mammals and results in a monoallelic,
parental-specific expression pattern. Most of these genes are located in clusters that are …
parental-specific expression pattern. Most of these genes are located in clusters that are …
A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
K Skourti-Stathaki, NJ Proudfoot - Genes & development, 2014 - genesdev.cshlp.org
R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized
with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally …
with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally …
Towards a therapy for Angelman syndrome by targeting a long non-coding RNA
Angelman syndrome is a single-gene disorder characterized by intellectual disability,
developmental delay, behavioural uniqueness, speech impairment, seizures and ataxia,. It …
developmental delay, behavioural uniqueness, speech impairment, seizures and ataxia,. It …
Angelman syndrome—insights into a rare neurogenetic disorder
K Buiting, C Williams, B Horsthemke - Nature Reviews Neurology, 2016 - nature.com
Angelman syndrome is a rare neurogenetic disorder that is characterized by microcephaly,
severe intellectual deficit, speech impairment, epilepsy, EEG abnormalities, ataxic …
severe intellectual deficit, speech impairment, epilepsy, EEG abnormalities, ataxic …