Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Hikikomori, a severe form of social withdrawal, has long been observed in Japan mainly
among youth and adolescents since around the 1970s, and has been especially highlighted …

Suicidal ideations (SI), often called suicidal thoughts or ideas, is a broad term used to
describe a range of contemplations, wishes, and preoccupations with death and suicide …

The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Chronic stress is a key risk factor for depression, and microglia have been implicated in the
pathogenesis of the disease. Recent studies show that the Nod-like receptor protein 3 …

Since December 2019, humankind has been experiencing a ravaging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus …

This narrative review examines the possible role of microglial cells, first, in
neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research …

Under physiological conditions 95% of the ingested essential amino acid tryptophan is
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …

Microglia, the immune cells of the brain, are important for neurodevelopment and have been
hypothesized to play a role in the pathogenesis of schizophrenia (SCZ). Although previous …