γδ T cells: origin and fate, subsets, diseases and immunotherapy
Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
hyperactivation, highlights the potential of immune renormalization as a promising strategy …
Decision checkpoints in the thymus
AC Carpenter, R Bosselut - Nature immunology, 2010 - nature.com
The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …
events, during which hematopoietic precursors give rise to T cells ready to respond to …
Deficient T cell fate specification in mice with an induced inactivation of Notch1
F Radtke, A Wilson, G Stark, M Bauer, J van Meerwijk… - Immunity, 1999 - cell.com
Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …
events. To explore the function of murine Notch1, an essential portion of the gene was …
Development of human lymphoid cells
B Blom, H Spits - Annu. Rev. Immunol., 2006 - annualreviews.org
The lymphocytes, T, B, and NK cells, and a proportion of dendritic cells (DCs) have a
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …
Notch 1–deficient common lymphoid precursors adopt a B cell fate in the thymus
A Wilson, HR MacDonald, F Radtke - The Journal of experimental …, 2001 - rupress.org
We have recently reported that Notch 1, a member of the Notch multigene family, is essential
for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated …
for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated …
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
K Germar, M Dose, T Konstantinou… - Proceedings of the …, 2011 - National Acad Sciences
Although transcriptional programs associated with T-cell specification and commitment have
been described, the functional hierarchy and the roles of key regulators in structuring …
been described, the functional hierarchy and the roles of key regulators in structuring …
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity
Some γδ and αβ T lymphocytes exhibit an “innate” phenotype associated with rapid cytokine
responses. The PLZF transcription factor is essential for the innate phenotype of NKT cells …
responses. The PLZF transcription factor is essential for the innate phenotype of NKT cells …
The thymus as an inductive site for T lymphopoiesis
M Ciofani, JC Zúñiga-Pflücker - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
Like all hematopoietic cells, T lymphocytes are derived from bone-marrow-resident stem
cells. However, whereas most blood lineages are generated within the marrow, the majority …
cells. However, whereas most blood lineages are generated within the marrow, the majority …
Induced pluripotent stem cell (iPSC)–derived lymphocytes for adoptive cell immunotherapy: recent advances and challenges
A Nianias, M Themeli - Current hematologic malignancy reports, 2019 - Springer
Abstract Purpose of Review In the rapidly developing field of adoptive cell immunotherapy,
there is urgent need for discoveries that would improve outcomes, extend the applicability …
there is urgent need for discoveries that would improve outcomes, extend the applicability …
Stage-specific and differential notch dependency at the αβ and γδ T lineage bifurcation
M Ciofani, GC Knowles, DL Wiest, H von Boehmer… - Immunity, 2006 - cell.com
Signals transduced by Notch receptors are indispensable for T cell specification and
differentiation of αβ T lineage cells. However, the role of Notch signals during αβ versus γδ T …
differentiation of αβ T lineage cells. However, the role of Notch signals during αβ versus γδ T …