Streptococcus pneumoniae Protein Vaccine Candidates: Properties, Activities and Animal Studies

SS Tai - Critical reviews in microbiology, 2006 - Taylor & Francis
Streptococcus pneumoniae is a causative agent for community acquired pneumonia,
bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant …

Serotype-independent pneumococcal vaccines

EN Miyaji, MLS Oliveira, E Carvalho, PL Ho - Cellular and Molecular Life …, 2013 - Springer
Streptococcus pneumoniae remains an important cause of disease with high mortality and
morbidity, especially in children and in the elderly. The widespread use of the …

Development of a Vaccine against Invasive Pneumococcal Disease Based on Combinations of Virulence Proteins of Streptococcus pneumoniae

AD Ogunniyi, M Grabowicz, DE Briles… - Infection and …, 2007 - Am Soc Microbiol
Current global efforts are focused on exploring alternative pneumococcal vaccine strategies,
aimed at addressing the shortcomings of existing formulations, without compromising …

Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae

IG Kong, A Sato, Y Yuki, T Nochi… - Infection and …, 2013 - Am Soc Microbiol
To establish a safer and more effective vaccine against pneumococcal respiratory infections,
current knowledge regarding the antigens common among pneumococcal strains and …

[HTML][HTML] A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae

JR Lane, M Tata, DE Briles, CJ Orihuela - Frontiers in Cellular and …, 2022 - frontiersin.org
Streptococcus pneumoniae (Spn), or the pneumococcus, is a Gram-positive bacterium that
colonizes the upper airway. Spn is an opportunistic pathogen capable of life-threatening …

[HTML][HTML] Menstrual hygiene management practices and associated health outcomes among school-going adolescents in rural Gambia

HM Nabwera, V Shah, R Neville, F Sosseh… - PLoS …, 2021 - journals.plos.org
Inadequate menstrual hygiene management (MHM) practices have been associated with
adverse health outcomes. This study aimed to describe MHM practices among schoolgirls …

Pneumococcal vaccines

DE Briles, JC Paton, R Mukerji, E Swiatlo… - Microbiology …, 2019 - Am Soc Microbiol
Streptococcus pneumoniae is a Gram-Positive pathogen that is a major causative agent of
pneumonia, otitis media, sepsis and meningitis across the world. The World Health …

Pneumococcal surface protein A (PspA) family distribution among clinical isolates from adults over 50 years of age collected in seven countries

SK Hollingshead, L Baril, S Ferro… - Journal of medical …, 2006 - microbiologyresearch.org
The pneumococcal surface protein PspA, a cell-wall-associated surface protein, is a
promising component for pneumococcal vaccines. In this study, the distribution of the PspA …

Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated …

M Darrieux, EN Miyaji, DM Ferreira… - Infection and …, 2007 - Am Soc Microbiol
PspA is an important pneumococcal vaccine candidate that is capable of inducing protection
in different animal models. Because of its structural diversity, a PspA-based vaccine should …

[HTML][HTML] The diversity of the proline-rich domain of pneumococcal surface protein A (PspA): Potential relevance to a broad-spectrum vaccine

R Mukerji, C Hendrickson, KR Genschmer, SS Park… - Vaccine, 2018 - Elsevier
Pneumococcal surface protein A (PspA) is a surface exposed, highly immunogenic protein
of Streptococcus pneumoniae. Its N-terminal α-helical domain (αHD) elicits protective …