In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein
structure, the synaptonemal complex (SC), that assembles between homologous …

Reproductive diseases are a long‐standing problem and have become more common in the
world. Currently, 15% of the world's population suffers from infertility, and half of them are …

Normal oocyte meiosis is a prerequisite for successful human reproduction, and
abnormalities in the process will result in infertility. In 2016, we identified mutations in …

The presence of population-specific phenotypes often reflects local adaptation or barriers to
gene flow. The co-occurrence of phenotypic polymorphisms that are restricted within the …

DNA double-strand breaks (DSBs) are induced by SPO11 during meiosis to initiate
recombination-mediated pairing and synapsis of homologous chromosomes. Germline …

Double-strand breaks (DSBs) initiate the homologous recombination that is crucial for
meiotic chromosome pairing and segregation. Here, we unveil mouse ANKRD31 as a …

Pairing and synapsis of homologous chromosomes during meiosis is crucial for producing
genetically normal gametes and is dependent upon repair of SPO11-induced double-strand …

Meiotic synapsis and recombination ensure correct homologous segregation and genetic
diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which …

Plant growth and fertility strongly depend on environmental conditions such as temperature.
Remarkably, temperature also influences meiotic recombination and thus, the current …

Faithful meiotic chromosome segregation and fertility require meiotic recombination
between homologous chromosomes rather than the equally available sister chromatid, a …