Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies
L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …
Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
F Nazio, M Bordi, V Cianfanelli, F Locatelli… - Cell Death & …, 2019 - nature.com
Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …
The chronic myeloid leukemia stem cell: stemming the tide of persistence
TL Holyoake, D Vetrie - Blood, The Journal of the American …, 2017 - ashpublications.org
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
Cancer stem cells—key players in tumor relapse
M Marzagalli, F Fontana, M Raimondi, P Limonta - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …
causes of death worldwide despite the constant development of novel therapeutic strategies …
Chronic myeloid leukemia stem cells
Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …
FOXO transcription factors in cancer development and therapy
A Coomans de Brachène, JB Demoulin - Cellular and molecular life …, 2016 - Springer
The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …
Targeting PI3K/AKT/mTOR network for treatment of leukemia
J Bertacchini, N Heidari, L Mediani, S Capitani… - Cellular and molecular …, 2015 - Springer
Objective Increased activity of PI3K/AKT/mTOR pathway has been observed in a huge
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …
Forkhead transcription factors in health and disease
L Herman, AL Todeschini, RA Veitia - Trends in Genetics, 2021 - cell.com
Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription
factors that has evolved by gene/genome duplication. FOX family members have undergone …
factors that has evolved by gene/genome duplication. FOX family members have undergone …
Chronic myeloid leukemia stem cells: targeting therapeutic implications
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …
Mechanisms of disease progression and resistance to tyrosine kinase inhibitor therapy in chronic myeloid leukemia: an update
Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …