The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

Cytosolic innate immune sensors are critical for host defense and form complexes, such as
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …

Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Inflammasomes are a group of multimolecular intracellular complexes assembled around
several innate immune proteins. Recognition of a diverse range of microbial, stress and …

The innate immune system in vertebrates and invertebrates relies on conserved receptors
and ligands, and pathways that can rapidly initiate the host response against microbial …

Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …