Recent advances in azlactone transformations

IFS Marra, PP de Castro… - European Journal of …, 2019 - Wiley Online Library
Azlactones, also known as oxazolones, are versatile building blocks in organic synthesis
due to the presence of multiple pro‐nucleophilic and electrophilic reactive sites. Recently …

Squaramide Catalyzed Asymmetric Synthesis of Five‐and Six‐Membered Rings

A Biswas, A Ghosh, R Shankhdhar… - Asian Journal of …, 2021 - Wiley Online Library
Chiral analogues of squaramides have been fruitful in organocatalyzed asymmetric
reactions over last decade. Alongside other H‐bonding catalysts like ureas, thioureas …

Asymmetric annulations based on cycloisomerization of cyclopropyl tethered allenyl ketones by bimetallic relay catalysis

J He, W Liu, J Zhang, Z Zhong, L Lin, X Feng - Science China Chemistry, 2023 - Springer
The diastereo-and enantioselective tandem cycloisomerization/[4+ 2]-cycloaddition reaction
of cyclopropyl tethered allenyl ketones with α, β-unsaturated carbonyl compounds was …

Chiral guanidine catalyzed cyclization reactions of 1, 3-enynes for lactone synthesis: switchable H-bond catalysis

Y Zhang, L Ning, T Zhu, Z Xie, S Dong… - Organic Chemistry …, 2024 - pubs.rsc.org
H-bonding catalysis has attracted much attention in asymmetric reactions. Taking advantage
of guanidine-amides as bifunctional organocatalysts, we successfully achieved cyclization …

Enantioselective Synthesis of Benzofuran-Fused N-Heterocycles via Chiral Squaramide Catalyzed [4 + 2] Cyclization of Azadienes with Azlactones

X Li, J Yan, J Qin, S Lin, W Chen, R Zhan… - The Journal of Organic …, 2019 - ACS Publications
An asymmetric cyclization reaction of azadienes and azlactones was investigated by
employing a Cinchona squaramide catalyst, which could afford a series of benzofuran-fused …

Organocatalytic asymmetric [4+ 2] cyclization of 2-benzothiazolimines with azlactones: access to chiral benzothiazolopyrimidine derivatives

Q Ni, X Wang, F Xu, X Chen, X Song - Chemical Communications, 2020 - pubs.rsc.org
An organocatalytic asymmetric domino Mannich/cyclization reaction between 2-
benzothiazolimines with azlactones has been successfully developed. With the bifunctional …

Regiodivergent Vinylogous–Cyclization Reactions of Cyclic α-Amide Enone Acceptors: Synthesis of Highly Enantioenriched Heterobicyclic Structures

Y Zhang, X Lu, Y Wang, H Xu, R Zhan, W Chen… - Organic …, 2019 - ACS Publications
A vinylogous addition–cyclization reaction of cyclic α-amide enones with good yields and
excellent regioselectivity catalyzed by cinchona squaramides has been reported. Using 4 …

Chiral Bis‐Oxalamide‐Rare Earth Complex Catalyzed Inverse‐ Electron‐Demand Asymmetric oxa‐Hetero‐Diels‐Alder Reaction for Optically Active Dihydropyran …

HD Yang, JB Chen, C Peng, WK Liu… - Advanced Synthesis …, 2022 - Wiley Online Library
Abstract Chiral bis‐oxalamide (CBOA)/rare‐earth metal complexes‐catalyzed asymmetric
inverse‐electron‐demand oxa‐hetero‐Diels‐Alder (HDA) reactions were investigated under …

Asymmetric construction of cyclobutanes via direct vinylogous Michael addition/cyclization of β, γ-unsaturated amides

Y Chen, Y Wang, S Wang, YY Ma, DG Zhao… - Organic …, 2020 - ACS Publications
The construction of cyclobutanes has attracted much attention because of its unique four-
membered ring skeleton. Herein, we report the highly enantioselective direct vinylogous …

Asymmetric addition and cycloaddition reactions with ylidene‐five‐membered heterocycles

R Torán, R Miguélez, A Sanz‐Marco… - Advanced Synthesis …, 2021 - Wiley Online Library
Five‐membered heterocycles bearing an exocyclic double bond have been successfully
used as substrates in asymmetric addition and cycloaddition reactions. Ylidene …