Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Background: Heart failure is a global public health issue that is associated with increasing
morbidity and mortality. Previous studies have suggested that mitochondrial dysfunction …

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dual kinase
that can phosphorylate its own activation loop on tyrosine residue and phosphorylate its …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Triple negative breast cancer (TNBC) remains challenging because of heterogeneous
responses to chemotherapy. Incomplete response is associated with a greater risk of …

Down syndrome (DS) caused by a trisomy of chromosome 21 (HSA21), is the most common
genetic developmental disorder, with an incidence of 1 in 800 live births. Its phenotypic …