Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small
intestine. In normal conditions, they function as the cornerstones of intestinal health by …

Zinc is an essential trace element for living organisms, and zinc homeostasis is essential for
the maintenance of the normal physiological functions of cells and organisms. The intestine …

Pollution by heavy metals limits the area of land available for cultivation of food crops. A
potential solution to this problem might lie in the molecular breeding of food crops for …

As a consequence of industrial development, soil Cd pollution leads to crop contamination
by Cd, posing a threat to food safety and human health. Excessive accumulation of Cd in …

Paneth cells are a group of unique intestinal epithelial cells, and they play an important role
in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as …

Antimicrobial peptides, in particular α-defensins expressed by Paneth cells, control
microbiota composition and play a key role in intestinal barrier function and homeostasis …

Over the last years, antimicrobial peptides (AMPs) have been the focus of intense research
toward the finding of a viable alternative to current antifungal drugs. Defensins are one of the …

Fibroblast Growth Factor 19–Mediated Up‐regulation of SYR‐Re... : Hepatology Fibroblast
Growth Factor 19–Mediated Up‐regulation of SYR‐Related High‐Mobility Group Box 18 …

Defensins protect human barriers from commensal and pathogenic microorganisms. Human
α-defensin 6 (HD-6) is produced exclusively by small intestinal Paneth cells but, in contrast …

Human α-defensin 5 (HD5) is a 32-residue cysteine-rich host-defense peptide that exhibits
broad-spectrum antimicrobial activity and contributes to innate immunity in the human gut …