Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

The surprising discovery that RNAs are the predominant gene products to emerge from the
human genome catalyzed a renaissance in RNA biology. It is now well-understood that …

The biology of healthy and disease-affected cells is often mediated by RNA structures,
desirable targets for small molecule chemical probes and lead medicines. Although …

RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …

The recognition of RNA functions beyond canonical protein synthesis has challenged the
central dogma of molecular biology. Indeed, RNA is now known to directly regulate many …

Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

Noncoding RNAs (ncRNAs) play pivotal roles in the regulation of gene expression and
represent a promising target for the development of new therapeutic approaches. Among …

RNA drug targets are pervasive in cells, but methods to design small molecules that target
them are sparse. Herein, we report a general approach to score the affinity and selectivity of …

RNA is challenging to target with bioactive small molecules, particularly those of low
molecular weight that bind with sufficient affinity and specificity. In this report, we developed …