[HTML][HTML] Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces

N Lee, S Hwang, J Kim, S Cho, B Palsson… - Computational and …, 2020 - Elsevier
Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …

[HTML][HTML] Molecular and biotechnological aspects of secondary metabolites in actinobacteria

R Salwan, V Sharma - Microbiological research, 2020 - Elsevier
The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …

Global analysis of the biosynthetic chemical space of marine prokaryotes

B Wei, GA Hu, ZY Zhou, WC Yu, AQ Du, CL Yang… - Microbiome, 2023 - Springer
Background Marine prokaryotes are a rich source of novel bioactive secondary metabolites
for drug discovery. Recent genome mining studies have revealed their great potential to bio …

Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

C Jo, J Zhang, JM Tam, GM Church, AS Khalil… - Materials Today Bio, 2023 - Elsevier
Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

[HTML][HTML] Strategies to establish the link between biosynthetic gene clusters and secondary metabolites

I Kjærbølling, UH Mortensen, T Vesth… - Fungal Genetics and …, 2019 - Elsevier
Filamentous fungi produce a vast number of bioactive secondary metabolites (SMs), some of
which have found applications in the pharmaceutical industry including as antibiotics and …

Bioactive compounds as an alternative for the sugarcane industry: Towards an integrative approach

A Molina-Cortés, M Quimbaya, A Toro-Gomez… - Heliyon, 2023 - cell.com
Here, a comprehensive review of sugarcane industrialization and its relationship with
bioactive compounds (BCs) detected in various products and by-products generated during …

[HTML][HTML] Insights into applications and strategies for discovery of microbial bioactive metabolites

D Maithani, A Sharma, S Gangola, P Chaudhary… - Microbiological …, 2022 - Elsevier
Secondary metabolites of microbial origin are structurally diverse and functionally versatile
compounds that offer selective advantages to the producing organism. Production of these …

Bioinformatic and reactivity-based discovery of linaridins

MA Georgiou, SR Dommaraju, X Guo… - ACS chemical …, 2020 - ACS Publications
Linaridins are members of the ribosomally synthesized and post-translationally modified
peptide (RiPP) family of natural products. Five linaridins have been reported, which are …

Genome In Silico and In Vitro Analysis of the Probiotic Properties of a Bacterial Endophyte, Bacillus Paranthracis Strain MHSD3

MO Diale, E Kayitesi, MH Serepa-Dlamini - Frontiers in Genetics, 2021 - frontiersin.org
Spore-forming Bacillus species are gaining interest in human health recently, due to their
ability to withstand the harsh environment of the gastrointestinal tract. The present study …

Structure elucidation and biosynthetic gene cluster analysis of caniferolides A–D, new bioactive 36-membered macrolides from the marine-derived Streptomyces …

I Pérez-Victoria, D Oves-Costales, R Lacret… - Organic & …, 2019 - pubs.rsc.org
Bioassay-guided isolation based on the antifungal activity of a culture broth of the marine-
derived actinomycete Streptomyces caniferus CA-271066 led to the discovery of new 36 …