Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles,
which are widely explored and utilized by the pharmaceutical industry for drug discovery …

The introduction of second-generation antipsychotics and cognitive therapies for
schizophrenia over the past two decades generated considerable optimism about …

Histamine has been one of the most studied substances in medicine, playing a major role in
diverse (patho) physiological processes. It elicits its multifaceted modulatory functions by …

We present a computational method for the reaction-based de novo design of drug-like
molecules. The software DOGS (D esign of G enuine S tructures) features a ligand-based …

Antihistamines, especially H1 antihistamines, are widely used in the treatment of allergic
diseases such as urticaria and allergic rhinitis, mainly for reversing elevated histamine and …

Considerable evidence has been collected indicating that histamine can modulate
proliferation of different normal and malignant cells. High histamine biosynthesis and …

Histamine is a potent mediator of inflammation and a regulator of innate and adaptive
immune responses. However, the influence of histamine on microglia, the resident immune …

High levels of histamine and histamine receptors (HRs), including H1R~ H4R, are found in
many different types of tumor cells and cells in the tumor microenvironment, suggesting their …