The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease

JC Evans, M Malhotra, JF Cryan… - British journal of …, 2016 - Wiley Online Library
Prostate specific membrane antigen (PSMA) otherwise known as glutamate
carboxypeptidase II (GCPII) is a membrane bound protein that is highly expressed in …

Uncovering the role of N-acetyl-aspartyl-glutamate as a glutamate reservoir in cancer

T Nguyen, BJ Kirsch, R Asaka, K Nabi, A Quinones… - Cell reports, 2019 - cell.com
Summary N-acetyl-aspartyl-glutamate (NAAG) is a peptide-based neurotransmitter that has
been extensively studied in many neurological diseases. In this study, we show a specific …

Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice

G Wang, A Manaenko, A Shao, Y Ou… - Journal of Cerebral …, 2017 - journals.sagepub.com
Heme-degradation after erythrocyte lysis plays an important role in the pathophysiology of
intracerebral hemorrhage. Low-density lipoprotein receptor-related protein-1 is a receptor …

Separate N‐acetyl aspartyl glutamate, N‐acetyl aspartate, aspartate, and glutamate quantification after pediatric mild traumatic brain injury in the acute phase

P Menshchikov, A Ivantsova… - Magnetic …, 2020 - Wiley Online Library
Purpose To separately measure N‐acetyl aspartul glutamate (NAAG), N‐acetyl aspartate
(NAA), aspartate (Asp), and glutamate (Glu) concentrations in white matter (WM) using J …

Development of neuropathology following soman poisoning and medical countermeasures

T Myhrer, E Mariussen, P Aas - Neurotoxicology, 2018 - Elsevier
Nerve agent-induced seizures can cause varying degrees of neuropathology depending on
level of poisoning and duration of seizing. The intention of this review was to validate a …

[HTML][HTML] Assessment of brain oxygenation imbalance following soman exposure in rats

K Lee, S Bohnert, Y Wu, C Vair, J Mikler, GC Teskey… - Neurotoxicology, 2018 - Elsevier
Nerve agents (NAs) are potent organophosphorus (OP) compounds with applications in
chemical warfare. OP compounds act by inhibiting acetylcholinesterase (AChE). Soman (O …

Flexibility of equine bioenergetics and muscle plasticity in response to different types of training: An integrative approach, questioning existing paradigms

C de Meeûs d'Argenteuil, B Boshuizen, M Oosterlinck… - PLoS …, 2021 - journals.plos.org
Equine bioenergetics have predominantly been studied focusing on glycogen and fatty
acids. Combining omics with conventional techniques allows for an integrative approach to …

A new approach towards highly sensitive detection of endogenous N-acetylaspartic acid, N-acetylglutamic acid, and N-acetylaspartylglutamic acid in brain tissues …

W Zhou, X Lv, S Zhang, Z Gao, B Li, X Wang - Microchimica Acta, 2024 - Springer
A novel in-tube solid-phase microextraction coupled with an ultra-high performance liquid
chromatography-mass spectrometry method has been established for simultaneous …

Metabolomic profiles predict clinical severity in patients with obstructive sleep apnea hypopnea syndrome

X Wang, J Zhao, X Wang, L Zhang - Journal of Clinical Sleep …, 2024 - jcsm.aasm.org
Study Objectives: Obstructive sleep apnea hypopnea syndrome (OSAHS) poses a
significant health hazard, as intermittent hypoxia inflicts damage throughout the body and is …

Quantitative T2 MRI is predictive of neurodegeneration following organophosphate exposure in a rat model

K Lee, S Bohnert, M Bouchard, C Vair, JS Farrell… - Scientific Reports, 2020 - nature.com
Organophosphorus compounds, such as chemical warfare nerve agents and pesticides, are
known to cause neurological damage. This study measured nerve agent-related …