[HTML][HTML] Serine-arginine protein kinases and their targets in viral infection and their inhibition
K Zheng, Z Ren, Y Wang - Cellular and Molecular Life Sciences, 2023 - Springer
Accumulating evidence has consolidated the interaction between viral infection and host
alternative splicing. Serine-arginine (SR) proteins are a class of highly conserved splicing …
alternative splicing. Serine-arginine (SR) proteins are a class of highly conserved splicing …
Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B
E Deau, MF Lindberg, F Miege, D Roche… - Journal of Medicinal …, 2023 - ACS Publications
Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) recently attracted attention due to their central involvement in various pathologies …
(CLKs) recently attracted attention due to their central involvement in various pathologies …
[HTML][HTML] A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?
AL Abdalla, G Guajardo-Contreras, AJ Mouland - Viruses, 2024 - mdpi.com
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of
cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently …
cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently …
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine
ABSTRACT RNA processing plays a key role in gene expression, allowing for increased
protein diversity and functional complexity. Consequently, modulating RNA processing can …
protein diversity and functional complexity. Consequently, modulating RNA processing can …
Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity
Clk1 kinase is a key modulator of the pre-mRNA alternative splicing machinery which has
been proposed as a promising target for treatment of various tumour types, Duchenne's …
been proposed as a promising target for treatment of various tumour types, Duchenne's …
[HTML][HTML] The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral …
L Shkreta, J Toutant, A Delannoy, D Durantel… - Oncotarget, 2024 - ncbi.nlm.nih.gov
The diheteroarylamide-based compound 1C8 and the aminothiazole carboxamide-related
compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of …
compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of …
[HTML][HTML] Identification of tyrphostin AG879 and A9 inhibiting replication of Chikungunya virus by screening of a kinase inhibitor library
Y He, Z Pan, Y Liu, L Jiang, H Peng, P Zhao, Z Qi, Y Liu… - Virology, 2023 - Elsevier
Chikungunya virus (CHIKV) is a globally public health threat. There are currently no
medications available to treat CHIKV infection. High-throughput screening of 419 kinase …
medications available to treat CHIKV infection. High-throughput screening of 419 kinase …
Exploring the Role that SR Kinases Play in Controlling Viral Infections with a Focus on HIV-1
S Dahal - 2023 - tspace.library.utoronto.ca
RNA processing plays a critical role in gene expression, enhancing protein diversity. SR
proteins are essential components of this regulation whose activity and localization are …
proteins are essential components of this regulation whose activity and localization are …