The role of CD45 and CD45‐associated molecules in T cell activation

JG Altin, EK Sloan - Immunology and cell biology, 1997 - Wiley Online Library
CD45 (lymphocyte common antigen) is a receptor‐linked protein tyrosine phosphatase that
is expressed on all leucocytes, and which plays a crucial role in the function of these cells …

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

KA Pape, ER Kearney, A Khoruts… - Immunological …, 1997 - Wiley Online Library
Adoptive transfer of TCR‐transgenic T cells uniformly expressing an identifiable TCR of
known peptide/MHC specificity can be used to monitor the in vivo behavior of antigen …

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

NE Buckley, KL McCoy, É Mezey, T Bonner… - European journal of …, 2000 - Elsevier
Cannabinoids have immunomodulatory as well as psychoactive effects. Because the central
cannabinoid receptor (cannabinoid CB1 receptor) is highly expressed in many neuronal …

Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity

H Gudmundsdottir, AD Wells… - The Journal of Immunology, 1999 - journals.aai.org
The adoptive transfer of TCR-transgenic T cells into syngeneic recipients allows
characterization of individual T cells during in vivo immune responses. However, the …

Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells

L Liu, L Li, J Min, J Wang, H Wu, Y Zeng, S Chen… - Cellular …, 2012 - Elsevier
Dendritic cells (DCs) are specialized antigen-presenting cells that are uniquely capable of
either inducing immune responses or maintaining a state of self-tolerance, depending on …

A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2–independent mechanism

A Khoruts, A Mondino, KA Pape, SL Reiner… - The Journal of …, 1998 - rupress.org
The adoptive transfer of naive CD4+ T cell receptor (TCR) transgenic T cells was used to
investigate the mechanisms by which the adjuvant lipopolysaccharide (LPS) enhance T cell …

Human CD14+ leukocytes acquire the phenotype and function of antigen‐presenting dendritic cells when cultured in GM‐CSF and IL‐4

SM Kiertscher, MD Roth - Journal of leukocyte biology, 1996 - Wiley Online Library
The combination of granulocyte‐macrophage colony stimulating factor (GM‐CSF) and
interleukin‐4 (IL‐4) induces the growth of antigen‐presenting cells (APC) from adherent …

T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture

J Satoh, YB Lee, SU Kim - Brain research, 1995 - Elsevier
The B7-1 and B7-2 expressed on the'professional'antigen-presenting cells (APC) of the
lymphoid system are counterreceptors for the T cell antigens CD28/CTLA-4. The B7/CD28 …

n‐Butyrate downregulates the stimulatory function of peripheral blood‐derived antigen‐presenting cells: a potential mechanism for modulating T‐cell responses by …

GA Böhmig, PM KRIEGER, MD Säemann… - …, 1997 - Wiley Online Library
Modulation of proliferative T‐cell responses by n‐butyrate has been suggested to result from
direct interference with cell cycle progression. Considering the important role of antigen …

Dangerous liaisons: the role of “danger” signals in the immune response to gene therapy

BD Brown, D Lillicrap - Blood, The Journal of the American …, 2002 - ashpublications.org
Recent studies in gene transfer suggest that the innate immune system plays a significant
role in impeding gene therapy. In this review, we examine factors that might influence the …