Alzheimer's disease is the most common form of dementia and the most common
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …

Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …

Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …

Alzheimer's disease (AD) is the most common form of age-related dementia, characterized
by progressive memory loss and cognitive disturbance. Mutations of presenilin 1 (PS1) and …

Intracellular deposition of misfolded protein aggregates into ubiquitin-rich cytoplasmic
inclusions is linked to the pathogenesis of many diseases. Why these aggregates form …

To determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal
dominant forms of EOAD (ADEOAD), we performed a population-based study in the city of …

Neurodegenerative diseases are among the most challenging diseases with poorly known
mechanism of cause and paucity of complete cure. Out of all the neurodegenerative …

Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous
system. In fact, it has been the very knowledge gained from genetic studies that has allowed …

Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked
to familial early onset forms of dementia. Mutation screening in these genes has been …

Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects
all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased …